This is a request for your suggestions to improve/amend CurePSP’s research plan, which is now two years old.
It was designed as a guide to grant applicants and donors who want to know what CurePSP is interested in funding. That’s not to say that we wouldn’t fund other things, but proposals that fit into the Roadmap’s model are viewed more favorably in our grant review process.
The elevator explanation of the model is that it uses unbiased gene searches to identify new risk genes, then finds drug targets among the proteins in the related gene products or cellular pathways, then tests those drugs in lab models, then turns to Pharma to develop those drugs clinically. Along the way, it calls for new models and new clinical markers to assist in the process.
Clearly, The Roadmap ignores important things such as symptomatic treatments, toxic etiologies, clinical characterization, epidemiology and neurophysiologic analysis, not to mention serendipitous neuroprotective treatments with unclear mechanism. But it provides a focus and an orientation.
So please use the Comments function to leave me your suggestions for improvement. Keep in mind that the Roadmap should remain relatively simple and generic. We don’t want to direct research from the top down. On the other hand, we don’t want the document to be so generic as to be useless.
Obviously, feel free to respond to others’ comments; and have fun!